FEMS Microbiology Reviews, fuab047 (2021) A population genetic perspective on the origin, spread and adaptation of the human malaria agents Plasmodium falciparum and Plasmodium vivax Abstract Malaria is considered one of the most important scourges that humanity has faced during its history, being responsible every year for numerous deaths worldwide. The disease is caused by […]
PLOS NEGLECTED TROPICAL DISEASES (2020) Human Plasmodium vivax diversity, population structure and evolutionary origin Plasmodium vivax Abstract More than 200 million malaria clinical cases are reported each year due to Plasmodium vivax, the most widespread Plasmodium species in the world. This species has been neglected and understudied for a long time, due to its lower […]
PLOS Pathogens (2020) The enigmatic mechanisms by which Plasmodium vivax infects Duffy-negative individuals Plasmodium vivax Abstract The absence of the Duffy protein at the surface of erythrocytes was considered for decadesto confer full protection against Plasmodium vivax as this blood group is the receptor for thekey parasite ligand P. vivax Duffy binding protein (PvDBP). However, […]
PLOS Biology (2018) Plasmodium vivax-like genome sequences shed new insights into Plasmodium vivax biology and evolution Abstract Although Plasmodium vivax is responsible for the majority of malaria infections outside Africa, little is known about its evolution and pathway to humans. Its closest genetic relative, P. vivax-like, was discovered in African great apes and is hypothesized […]
Science Advances. 7 : eabc3713 (2021) Population genomic evidence of Plasmodium vivax Southeast Asian origin Abstract Plasmodium vivax is the most common and widespread human malaria parasite. It was recently proposed that P. vivax originates from sub-Saharan Africa based on the circulation of its closest genetic relatives (P. vivax-like) among African great apes. However, the limited number of […]
