Evolution of monkey Plasmodium parasites in French Guiana

logo virginie rougeron researcher cnrs laboratory research
A research experience from the field to the laboratory

a research experience from the field to the laboratory

malaria continues to select for sickle cell trait in central africa

This ORA research project will include three main task that will be mainly performed in French Guiana

Current Projects

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Contact

  • REHABS International Research Lab South Afrrica
  • virginie.rougeron@cnrs.fr
  • 06 46 64 23 18

More information about the project

evolution adaptation parasites french guiana monkey plasmodium

@ B. De Thoisy

Origin and Adaptation of parasites to new environments: the case of monkey malarial agents in French Guiana CEBA Annual Call ORA – 2021 – 2023

Abstract

In this ORA project, our aim is to get clues on how P. simium and P. brasilianum emerged in Americas. Since to understand the origin of a pathogen species into a new host environment, it is necessary to determine the set of host species in which the pathogen naturally circulates, the first task of the project will be to proceed to a more thorough examination of the natural host range of P. simium and P. brasilianum in American nonhuman primates. The second task, based on genomes sequencing data, will be to study the population genetic structure of these Plasmodium species in America. Finally, the last task will aim to examine lineage specific genomic features of these monkey Plasmodium species to determine if and how these parasites genetically adapted to its different host species. This ORA research project will include three main task that will be mainly performed in French Guiana, in collaboration with CEBA researchers and their institutions.

Funding

CEBA Annual Call – ORA project – 2021 – 2023 “Origin and Adaptation of parasites to new environments: the case of monkey malarial agents in French Guiana”

Partners

Main results

No detection of P. simium circulation in French Guiana

New P. brazilianum genomes from French Guiana

@ B. De Thoisy

Because the project recently started, samples are being screened and all genomic data are currently being produced.

Studied sampling distribution

Figue legend : Origin of animal samples that will be screened for the presence of Plasmodium parasites in the ORA project. @ V. Rougeron

Main publications

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Portfolio

Photos legends : Cebus Olivera, French Guiana. @ B. De Thoisy – Landscape, French Guiana. @ V. Rougeron – Monkey, French Guiana. @ B. De Thoisy – House, French Guiana @ V. Rougeron

Malarial agent in French Guiana

Collaborators involved

franck prugnolle crees researcher cnrs

Franck PRUGNOLLE

Franck PRUGNOLLE

(DR1, MIVEGEC, France), an evolutionary biologist and geneticist, help in data analysis and publication writing.
benoit de thoisy collaboration team

Benoit DE THOISY

Benoit DE THOISY

(veterinary and researcher at Pasteur Institute of Cayenne, French Guyana, France), provide monkey samples from French Guyana and help in publication writing.
researcher duron olivier

Olivier DURON

Olivier DURON

(DR2, MiVEGEC, France), help in publication writing.
researcher arnathau celine

Céline ARNATHAU

Céline ARNATHAU

(IE, MiVEGEC, France), specialist in molecular biology and Plasmodium, be in charge of the molecular bench-work.
michael fountain researcher

Michael FONTAINE

Michael FONTAINE

(CRCN, MIVEGEC, France), specialist in genomics and evolutionary adaptation of organisms, help in genomic data analysis and publication writing.
fanny degrugillier research virginie rougeron evolution adaptation

Fanny DEGRUGILLIER

Fanny DEGRUGILLIER

(IR, MiVEGEC) is managing the entire project.