reproductive strategies and population structure in Leishmania substantial
characterization of a genogroup sapovirus isolated from chimpanzees in the republic of congo
the aim of the current project is to better understand and evaluate the role of the DBP ligand proteins of P. vivax and the two P. vivax-like species
- REHABS International Research Lab South Afrrica
- 06 46 64 23 18
@ V. Rougeron
Species very close genetically to P. vivax were recently discovered by the SHAPE team of the MiVEGEC laboratory, in African great apes (gorillas, Gorilla gorilla and chimpanzees, Pan troglodytes troglodytes), called Plasmodium vivax-like 1 and Plasmodium vivax-like 2. The team generated the first reference genomes of these new species, and was also able to demonstrate the functional existence (unspecified gene and absence of STOP codon in the coding sequence) in P. vivax-like 1 and P. vivax-like 2 of the ligand protein DBP. In this context, the aim of the current project is to better understand and evaluate the role of the DBP ligand proteins of P. vivax and the two P. vivax-like species during the invasion of red blood cells of their respective vertebrate hosts.
ANR T-ERC EVAD
@ V. Rougeron
The project recently started, and samples are being tested for different rosseting assays.
Photos legends : COS7 culture and rosetting assays.